The NMDA antagonist dizocilpine (MK-801) reverses haloperidol-induced movement initiation deficits
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منابع مشابه
The NMDA antagonist dizocilpine (MK-801) reverses haloperidol-induced movement initiation deficits.
The present study shows that systemic dopamine receptor blockade impaired movement initiation of rats, trained in a simple reaction time task for rapid initiation of locomotion in response to a combined optic/acoustic cue. Reaction time, movement time and the accelerative force were recorded for each initiation of locomotion. Results indicate a dose-related increase of reaction time following s...
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Effect of clozapine on MK-801-induced hyperlocomotion and stereotypy as well as open field behavior was studied. Clozapine (0.1-7.5 mg/kg) dose-dependently blocked MK-801(0.5 mg/kg)-induced stereotypy. Both total and ambulatory responses were blocked by even the lower doses (0.1-0.5 mg/kg) of clozapine. In open field test, clozapine selectively blocked hyperambulation induced by MK-801 (0.1 mg/...
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ژورنال
عنوان ژورنال: Behavioural Brain Research
سال: 1990
ISSN: 0166-4328
DOI: 10.1016/0166-4328(90)90151-4